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doi: 10.1038/npp.2015.47, 61 HealthU

Semaglutides introduction of a fatty acid side chain at position 26 Lys allows reversible binding to plasma albumin and reduces renal clearance, and substitution of amino acids at positions 8 and 34 with Aib and Arg avoids its degradation by DPP-4 and prevents fatty acid binding at the wrong site, resulting in a once-weekly dosing (Lau et al., 2015